Protein polymorphism is studied in more than 400 serum samples obtained from
NJ, three population groups in Korea, and the characterization of the population groups has been performed. The PLG, Gc, Tf and a-l-antitrypsin subtype polymorphisms were determined after isoelectric focusing while Hp, Bf and C3 were studied by means of conventional electrophoretic techniques on starch gel, cellogel and agarose gel,
h respectively.
Hart. The Korean frequencies for the two common alleles (Tf*C1 and Tf*C2) are close
tcd to the corresponding figures observed in other Asiatic populations. However, the Tf*C2 is more frequent in our samples than in Japanese and Chinese and it is significantly higher compared to European and African populations. Tf*D and Tf*B variants are observed, their frequencies being low compared to that in other geographic regions. The a-l-antitrypsin polymorphism corresponds to the presence of the three Pi*M sub-types and the polymorphic gene frequencies are in accordance with earlier known estimates in Chinese populations. Three variants, Pi*J, Pi*S and Pi*G are observed in the frequencies less than 0.01. The Bf*F frequency in our samples is higher than those in Chinese, and a rare Bf*SO.7 variant is also found, its frequency being low compared to that in other geographic regions, however. The Korean frequencies of the three common Gc alleles (Gc*1F, Gc*1S and Gc*2) are not significantly different from those found in Japanese. Approximately the same Hp*1 frequency as observed in the Korean populations is found among various ethnic groups of Orientals. The frequencies of PLG*1 and PLG*2 are very similar to the corresponding values in Japanese, and our frequency of C3*S corresponds well with the previous observations among different Oriental populations.
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